The perfect combination for cartilage repair.
CartiONE

Why CartiONE?

CartiONE is the first cartilage repair technology that uses patient’s own chondrocytes to generate hyaline cartilage in one surgery
 
CartiONE Benefits
Single Surgery
  • Cell mix prepared in one hourwithin the operating room
  • No cell culturing
  • No second implantation surgery required
Freshly Isolated Chondrocytes
  • No cell culture ensures cells maintain their intrinsic potential to generate hyaline cartilage tissue1
Patient's Own Cells
  • No risk of disease transfer
  • No risk of rejection
Cell Combination
  • Cellular interaction supports cartilage formation 2,3,4
  • No external growth factors required
  • Inhibits hypertrophy (overgrowth of cartilage) frequently related to the application of (bone-marrow derived) stem cells 5
Wide Selection of Membranes/Carriers
  • Surgeon can select the carrier based on defect type and preference
  • Patient-specific treatment

The Cartilage Challenge

Cartilage defect causes knee pain
It is estimated that over 1.2 million articular cartilage injuries occur annually in the U.S. and Europe. Cartilage injuries typically degenerate into more severe cartilage defects. These patients suffer from knee pain and functional impairment resulting in a decrease in quality of life and eventually in total knee replacement—if untreated. There are many available technologies for the treatment of articular cartilage defects.However, none of them provides a straightforward long-term solution. 

 

None of the currently available techniques have been successful in addressing all key requirements: single procedure, long-term pain relief, autologous-chondrocyte-based, high-quality repair, and easy delivery. CartiONE addresses all these requirements.

 
Feature ACI Micro-fracture Mosaic-plasty Acellular membrane CartiONE
Single Procedure          
Long-Term Pain Relief          
Chondrocyte-Based          
High Quality Repair          
Broad Range of Lesion Sizes         *   *
Full Defect Filling         *   *
Easy to Deliver          
Cost $$$$$ $ $$ $$ $$$
* Depends on the membrane/carrier.
 
  1. Darling EM, Athanasiou K a. Rapid phenotypic changes in passaged articular chondrocyte subpopulations. J. Orthop. Res. 2005;23(2):425-432. doi:10.1016/j.orthres.2004.08.008.
  2. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J. Cell. Biochem. 2006;98(5):1076-84. doi:10.1002/jcb.20886.
  3. Wu L, Sc B, Leijten JCH, et al. Trophic Effects of Mesenchymal Stem Cells Increase Chondrocyte Proliferation and Matrix Formation.  2011;17. doi:10.1089/ten.tea.2010.0517.
  4. De Windt TS, Hendriks JAA, Zhao X, et al. Concise review: unraveling stem cell cocultures in regenerative medicine: which cell interactions steer cartilage regeneration and how? Stem Cells Transl. Med. 2014;3(6):723-733.
  5. Cooke ME, Allon AA, Cheng T, et al. Structured three-dimensional co-culture of mesenchymal stem cells with chondrocytes promotes chondrogenic differentiation without hypertrophy. Osteoarthr. Cartil. 2011:1-9. doi:10.1016/j.joca.2011.07.005.